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Biology News - February 2007

FOXO Transcription Factors

February 19th 2007 23:23
Biology Lab
Current Biology has a quick guide to FOXO transcription factors. FOXO regulates longevity and tumor suppression. Scientists are able to manipulate the longevity gene in invertebrates, but mammals have proven more difficult to understand.


Source: Current Biology, Vol 17, R113-R114, 20 February 2007

FOXO Transcription Factors by Matthew E. Carter and Anne Brunet
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The Basics of Biofuels

February 19th 2007 22:40
Chris Somerville has written a primer on biofuels and published it in the current issue of Current Biology. The primer discusses how energy is measured and how to compare various sources of fuel. It then goes on to talk about corn and cane ethanol, biodiesel, cellulosic ethanol, some future possibilities for biofuels, and an alternative idea to biofuels.

It's an interesting read and all scientific terms are defined in the article.

Source: Current Biology, Vol 17, R115-R119, 20 February 2007
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Prion Disease Reversed in Mice

February 1st 2007 19:21
Published in the current issue of Neuron, Mallucci, et al., not only stopped the production of prions in an infected mouse, but reversed the brain damage so that the mouse recovered its normal abilities.

Prion diseases are caused by a "broken" protein that damages healthy proteins in mammalian brains. In humans, the disease is called Creuzfeld-Jacobs disease (CJd) and can happen spontaneously or can be caused by ingesting infected materials (such as beef from an infected cow). Prion disease in cattle is called Bovine Spongiform Encephalopathy (BSE) or Mad Cow.

Currently, there is no cure for prion diseases, and the mice in the study were genetically engineered so that the researchers could turn off the prion production in their bodies. But the possibility of a cure looks so much closer now.

Source: Neuron, Vol 53, 01 February 2007



"Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice" by Giovanna R. Mallucci, Melanie D. White, Michael Farmer, Andrew Dickinson, Husna Khatun, Andrew D. Powell, Sebastian Brandner, John G.R. Jefferys, and John Collinge
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